blood smear

• related: Hemeonc

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Overview

• look in monolayer region, red cells not overlapping but almost touching

Terminology

• background: not significant
• trace: not totally confident real finding
• 1+ first step with confidence abnormal
• 4+ most ever seen

RBC

• anisocytosis: varied size
• poikilocytosis: varied shape

AIHA

• spherocytosis, AIHA
• reticulocytosis: slightly larger and darker, multiple RBC size/colors

• Direct: patient RBC, patient antibody
• Indirect: patient antibody only. React with transfused RBC

Examples

• rouleaux

• IDA
• RBC should be size of lymphocyte nucleus, smaller here
• over-represented central pallor

• tear drop cells, dacrocytes
• evidence of marrow invasion

• TTP
• MAHA

WBC

• CLL, mature lymphocytes

• different white cells
• CML: varying maturation, whole spectrum of maturation

• blasts, high nucleus to cytoplasm ratio
• ALL

• APL, AML
• give ATRA